Diseased bees will eat through icing sugar to greet their new queen
The island's bees are disease-free after Tynwald passed a law in 1987 to ban the import of foreign bees.
The queens will replace infected ones and may gradually spawn new colonies.
Our bees are among the healthiest in the world
Harry Owens, bee disease officer and inspector
Manx government bee disease officer and inspector, Harry Owens said: "Our bees are among the healthiest in the world and it would be nice to see if they could take over diseased colonies."
If successful, it is possible that the Isle of Man may export healthy bees as a commercial venture, he said.
Kill the queen
"The keeper will take out and kill the existing queen and put the cage, which contains a bit of icing sugar, in the hive.
"The diseased worker bees will eat through the icing to release the queen, by which time they will have accepted her as their own," said Mr Owens.
The queen's and drones' healthy offspring will then repopulate the hive over a 46-day period as the last of the diseased bees die off, said Mr Owens.
UK agriculturalists and ecologists are alarmed by the extent of bee population declines because of their crucial role in pollinating crops.